Chymase inhibition reduces infarction and matrix metalloproteinase-9 activation and attenuates inflammation and fibrosis following acute myocardial ischemia/reperfusion
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چکیده
1 Title Page Chymase inhibition reduces infarction and matrix metalloproteinase-9 activation and attenuates inflammation and fibrosis following acute myocardial ischemia/reperfusion Shizu Oyamada, MD, Cesario Bianchi, MD, PhD, Shinji Takai, PhD, Louis M. Chu, MD, Frank W. Sellke, MD Cardiovascular Research Center (SO, CB, LC, FS) Division of Cardiothoracic Surgery (SO, CB, LC, FS) Rhode Island Hospital and Alpert Medical School of Brown University (SO, CB, LC, FS) Department of Pharmacology (ST) Osaka Medical College (ST) JPET Fast Forward. Published on July 27, 2011 as DOI:10.1124/jpet.111.179697
منابع مشابه
Chymase inhibition reduces infarction and matrix metalloproteinase-9 activation and attenuates inflammation and fibrosis after acute myocardial ischemia/reperfusion.
Chymase is activated after acute myocardial ischemia/reperfusion (AMI-R) and is associated with an early activation of matrix metalloproteinase-9 (MMP-9), which increases infarct size after experimental AMI, and late fibrosis. We assessed the effect of chymase inhibition on myocardial protection and early signs of fibrosis after AMI-R. Fourteen pigs underwent AMI-R and received intravenously ei...
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